If you have a problem that you can't find a good solution for, you should turn to nature to see if microbes have figured it out already. They are simply amazing in their capabilities. Crops can't grow without them, alcohol can't be made without them, your stomach can't digest food without them, antibiotics can't be made without them, solid waste can't be broken down without them and most wastewater treatment can't function without them.
If the above list represents just a small portion of what they are required for, imagine putting them to work improving areas they are not. Tell us more about your headache and see if we can manufacture a microbe that delivers what you require.